Matthew A. Hook, M.D., F.A.C.C.

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  • Spending time at the YMCA
  • Being with family
  • Running and cycling



  • Fellowship, Cardiovascular Disease and Interventional Cardiology, The Cleveland Clinic Foundation, Cleveland, OH


  • Residency: Internal Medicine, University Of Virginia Health System


  • Medical Degree: Vanderbilt University School of Medicine, Nashville, TN
  • Undergraduate Degree: Columbia University School of Engineering and Applied Sciences, New York, NY


  • Interventional Cardiology
  • Nuclear Cardiology
  • Cardiovascular Disease
  • Internal Medicine


  • Chief Cardiology Fellow, Cleveland Clinic, 2003-04
  • Chief Resident, Internal Medicine, University of Virginia Hospitals, 2000-01
  • North Carolina Medical Society
  • The Cleveland Clinic Foundation Innovator Award
  • University of Virginia Resident Teaching Award
  • Alpha Omega Alpha
  • Fellow, The American College of Cardiology


  • Complex coronary and chronic total occlusion
  • Lower extremity intervention
  • Carotid artery and acute stroke intervention



  • Hook M, Griffin BG, Topol EJ, Roffi M. Ventricular septal defect. Manual of Cardiovascular Medicine for PDA. 2003.
  • Hook M, Griffin BG, Topol EJ. Ventricular septal defect. Manual of Cardiovascular Medicine Second Edition. 2004.
  • McRae T, Messerli A, Hook M. guest eds., Griffin BG, Topol EJ. Ed., Manual of Cardiovascular Medicine Second Edition. 2004.
  • Hook M, Bhatt DL. Cardiovascular emergencies. Cleveland Clinic Disease Management Project. 2003.
  • Karha J, Hook M, Brener S. A review of primary PCI for acute myocardial infarction. The Cleveland Clinic Journal of Medicine. 2004.
  • Charles PD, Davis TL, Shannon KM, Hook M, Warner JS. Dystonia: treatment with botulinum toxin. South Med J. 1997;90:522-525.


  • Hook M, Zhou Z, Kiedrowski M, et al. Interferon-beta attenuates atherosclerotic plaque progression and decreases macrophage content of lesions. JAAC. 2005;45Suppl: A:398A.
  • Gurm H, Rajagopal V, Vivek D, Hook M, Bhatt DL, Lincoff AM. The safety of bivalirudin in patients undergoing rotational atherectomy. Submitted TCT 2005 Sessions.
  • Hook M, Seshadri N, Messerli AM, Chiu J, Pearce GL, Sprecher DL. Clustering of novel risk factors correlates with traditional risk burden and coronary artery disease. AHA Annual Sessions 2003.
  • Seshadri N, Ahmed M, Hook M, et al. Higher plasma total homocysteine levels are associated with cardiac allograft vasculopathy determined by intravascular ultrasound. ACC Annual Sessions 2004.
  • Seshadri N, Ahmed M, Hook M, et al. Association of hypertension with allograft rejection following orthotopic heart transplantation. ACC Annual Sessions 2004.


  • Immunomodulation and Atherosclerosis Heart Center Grand Rounds, The Cleveland Clinic Foundation, Cleveland, OH, 2004
  • Pleiotropic Effects of Statins, The Intercontinental Hotel, Cleveland, OH, 2004
  • Pulmonary Complications of Dermatomyositis, American College of Physicians Research Symposium, Charlottesville, VA, 1998
  • Interesting Case Studies in Medicine, Internal Medicine Grand Rounds, University of Virginia Health Center, Charlottesville, VA, 1998


  • 3-bromotyrosine as a marker of eosinophilic peroxidase activity after drug-eluting stent implantation. Investigating a biomarker of eosinophil activation in patients receiving drug-eluting stents and its correlation to vascular histology
  • Interferon-beta enhancement of the T-cell type 2 response in atherosclerosis. Using a murine model of atherosclerosis to determine the effect of exogenous interferon-beta administration on plaque progression and myocardial infarction size


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