R. Lee Jobe, M.D., F.A.C.C., F.S.C.A.I.

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CLINICAL AREAS OF EXPERTISE

  • Diagnostic coronary angiography
  • Coronary intervention, especially complex interventions
  • Peripheral angiography and intervention
  • Permanent pacemaker placement
  • Noninvasive cardiology including stress testing and echocardiography

 

APPOINTMENTS & COMMITEES

  • Area Councilor, North Carolina Chapter; American College of Cardiology; 1998-2002 and 2008 – present
  • STEMI Care committee; Wake Medical Center; 1998-present
  • Invasive Cardiology Committee (Chairman 2004, 2007); Wake Medical Center; 1996-present
  • Credentials Committee, Wake Medical Center; 2000-2002
  • Congestive Heart Failure Committee; Wake Medical Center; 1997-1999
  • Pharmacy Committee, Cabarrus Memorial Hospital; 1995-1996
  • Blood and Surgical Utilization Committee, Cabarrus Memorial Hospital; 1994-1996
  • Medical Director, Cardiac Rehabilitation Program; Cabarrus Memorial Hospital; 1994-1996

FELLOWSHIP & POSTGRADUATE TRAINING

  • Fellowship, Cardiovascular Disease and Interventional Cardiology, Vanderbilt University Medical Center, Nashville, TN

INTERNSHIP/RESIDENCY

  • Residency: Internal Medicine, Carolinas Medical Center, Charlotte, NC

EDUCATION

  • Medical Degree: University of North Carolina at Chapel Hill
  • Undergraduate Degree: University of North Carolina at Chapel Hill

CERTIFICATIONS

  • National Board of Medical Examiners, Diplomate
  • American Board of Internal Medicine, Diplomate
  • American Board of Internal Medicine, Cardiovascular diseases, Diplomate
  • Nuclear Radioisotope License, North Carolina

PROFESSIONAL MEMBERSHIPS

  • Alpha Epsilon Delta Premedical Honor Society
  • The American College of Cardiology, Fellow
  • Society of Cardiac Angiography and Intervention, Fellow
  • North Carolina Medical Society, Member
  • Wake County Medical Society, Member
  • UNC Alumni Association, Life Member
  • Mensa USA, Life Member

SPECIALTIES

  • Diagnostic Cardiac Catheterization
  • Interventional Cardiology
  • Nuclear Cardiology
  • Noninvasive Cardiology including Echo and Stress Echo
  • Permanent Pacemaker Implantation
  • Peripheral Angiography and Intervention
  • Transcatheter Aortic Valve Replacement (TAVR)

  • PUBLICATIONS/PRESENTATIONS/RESEARCH

RESEARCH & PUBLICATIONS
Bibliography:

  1. Jobe RL, Gallagher JJ. Use of Adenosine in a hypotensive patient with Wolff-Parkinson White syndrome and supraventricular tachycardia. American Heart Journal 121:1239-1240, 1991.
  2. Jobe RL, Byrd BF III. Echocardiography in the diagnosis and management of infective endocarditis. Infectious Disease Newsletter 10:69-71, 1991.
  3. Stacy GP, Jr., Jobe RL, Taylor LK, Hansen DE. Stretch-induced depolarizations as a trigger of arrhythmias in isolated canine left ventricles. American Journal of Physiology 263:H613-623, 1992.
  4. Jobe RL, Forman MB. Focal pulmonary embolism presenting as diffuse pulmonary edema. Chest 103:644-646, 1992.
  5. Hansen DE, Stacy GP, Jr., Taylor LK, Jobe RL, Wang Z, Denton PK, Alexander J, Jr. Calcium- and sodium-dependent modulation of stretch-induced arrhythmias in isolated canine ventricles. American Journal of Physiology 268:H1803-1813, 1995.
  6. Mann T, Cowper PA, Peterson ED, Cubeddu G, Bowen J, Giron L, Cantor WJ, Newman WN, Schneider JE, Jobe RL, Zellinger MJ, Rose GC. Transradial coronary stenting: comparison with femoral access closed with an arterial suture device. Catheter Cardiovasc Interv 49:150-6, 2000.
  7. Mann T, Cubeddu RJ, Raynor L, Bowen J, Schneider JE, Rose G, Cubeddu G, Raza JA, Jobe RL, Newman W, Zellinger M. Coronary stenting in stable patients: identification of a low-risk subgroup that may not require adjunctive antiplatelet therapy. Catheter Cardiovasc Interv 58: 459-66, 2003.
  8. Wood F, Mann T, Jobe RL, Arrowood M. Transradial subclavian and coronary stenting in a single procedure. J Invasive Cardiol 16: 596-8, 2004
  9. Wood F, Bazemore E, Schneider JE, Jobe RL, Mann T. Technique of left main stenting is dependent on lesion length and distal branch protection. Catheter Cardiovasc Interv 65: 499-503, 2005.

Abstracts:

  1. Jobe RL, Taylor LK, Wang Z, Hansen DE. The digitalis glycosides revisited: Inhibition of stretch-induced arrhythmias by oubain in the isolated canine heart. Circulation 1992.
  2. Jobe RL, Kasper EK, Yeoh TK, Groves J, Lange DH, Frist WH. Clinical and hemodynamic determinants of maximum exercise oxygen consumption one year after orthotopic heart transplant. Journal of Heart and Lung Transplantation, 1993.
  3. Jobe RL, Taylor LK, Wang Z, Berger CM, Stacy GP, Jr., Hansen DE. Contribution of calcium release from sarcoplasmic reticulum in the genesis of stretch-induced arrhythmias. Circulation 88:I-30, 1993.
  4. Jobe RL, Taylor LK, Wang Z, Hansen DE. Metabolic regulation of stretch-induced arrhythmias: evidence of elevated cyclic AMP in the isolated canine ventricle. Circulation 88:I-30, 1993.
  5. Taylor LK, Jobe RL, Wang Z, Denton PK, Barthefl SW, Hansen DE. Mechanotransduction signaling of the left ventricle: evidence for sodium dependent activation of stretch-induced arrhythmias. Circulation 88:I93, 1993.

Presentations:

  1. Jobe RL, Willis PW, Hoole AJ. A clinical study of the fourth heart sound: incidence among patients at North Carolina Memorial Hospital as measured by house officer examination compared with phonocardiography and apexcardiography. North Carolina Chapter meeting, American College of Physicians, 1988.
  2. Jobe RL, Taylor LK, Wang Z, Stacy GP, Jr., Hansen DE. Intracellular calcium processing and the initiation of stretch-induced arrhythmias in the isolated canine heart: divergent effects of ryanodine, caffeine, and forskolin. Finalist, Elliot Newman Award, Vanderbilt University Research Forum, 1992.
  3. Jobe RL, Taylor LK, Wang Z, Hansen DE. The digitalis glycosides revisited: Inhibition of stretch-induced arrhythmias by oubain in the isolated canine heart. American Heart Association Scientific Sessions, 1992.
  4. Jobe RL, Kasper EK, Yeoh TK, Groves J, Lange DH, Frist WH. Clinical and hemodynamic determinants of maximum exercise oxygen consumption one year after orthotopic heart transplantation. International Society for Heart and Lung Transplantation, 1993.
  5. Jobe RL, Taylor LK, Wang Z, Berger CM, Stacy GP, Jr., Hansen DE. Contribution of calcium release from sarcoplasmic reticulum in the genesis of stretch-induced arrhythmias. American Heart Association Scientific Sessions, 1992.
  6. Jobe RL, Taylor LK, Wang Z, Hansen DE. Metabolic regulation of stretch-induced arrhythmias: evidence of elevated cyclic AMP in the isolated canine ventricle. American Heart Association Scientific Sessions, 1993.
  7. Taylor LK, Jobe RL, Wang Z, Denton PK, Barthefl SW, Hansen DE. Mechanotransduction signaling of the left ventricle: evidence for sodium dependent activation of stretch-induced arrhythmias. American Heart Association Scientific Sessions, 1993.
  8. Jobe, RL. Complications of Cardiac Catheterization. Cardiology Grand Rounds, Wake Medical Center, Raleigh, NC, Raleigh, NC. 2003.
  9. Jobe, RL. Drug Eluting Stents: State of the Art. Medical Grand Rounds, Greensboro, NC and Wilmington NC, 2004
  10. Jobe, RL. ACC/AHA STEMI Care Guidelines Update. Cardiology Grand Rounds. Louisburg, NC, 2005.
  11. Jobe, RL. Plavix Resistance. Cardiology Clinical Case Conference. Wake Medical Center, Raleigh, NC. 2006.
  12. Jobe, RL. PCI: Radial Approach vs Femoral Approach. Tremblant National Cardiology Meeeting, Montreal, Canada. 2006.
  13. Jobe, RL. Fellows Conference on Transradial PCI. TCT National Meeting. 2006, 2007.
  14. Jobe, RL. Drug Eluting Stents: State of the Art. Cardiology Grand Rounds. Richmond VA. 2007.
  15. Jobe, RL. Abbott Xience V Stent Program. Cardiology Grand Rounds. Charlotte, NC. 2007.
  16. Jobe, RL. Cardiac Catheterization and Intervention: Introduction and Cases. Terumo National Sales Meeting. Key Biscayne FL. 2008.
  17. Jobe, RL. PCI for Acute Myocardial Infarction. Medical Grand Rounds. Wake Medical Center, Raleigh, NC. 2008
  18. Jobe, RL. Outline of a Code STEMI Program at a Regional Heart Center. NC/SC ACC Regional Meeting. 2009.
  19. Jobe, RL. Put a Little Love in Your Heart. Community Awareness Program, Knightdale, NC. 2009
  20. Jobe, RL. When to Take Chest Pain Seriously. Community Awareness Program. Raleigh, NC and Wake Forest, NC. 2009.
  21. Jobe, RL. Cardiologist for a Day, ACC Sponsorship of Elected Officials in Cardiac Cath Lab, WakeMed, Raleigh, NC. 2010
  22. Jobe, RL. Transradial Catheterization and Intervention. Video Interview for Heart.org taped at TCT. Washington DC. 2010.
  23. Jobe, RL. Coronary Laser Atherectomy. Cardiology Grand Rounds. Wake Medical Center. Raleigh, NC. 2011.
  24. Jobe, RL. Fractional Flow Reserve, Case Presentation and Review. Cardiology Grand Rounds. Wake Medical Center. Raleigh, NC. 2011.
  25. Jobe, RL. The Way to a Woman’s (Healthy) Heart. Community Awareness Program. Halifax County NC. 2011
  26. Jobe, RL. TransRadial Access: Saves Money, Saves Lives. Presented at NC Chapter ACC Meeting. Asheville, NC. 2011
  27. Jobe, RL. PCI at Wilson Medical Center: Our one-year experience. Presented to WilMed Medical Staff, Wilson NC, 2012
  28. Jobe, RL. PCI in Hospitals Without On-site Surgical Backup: The Wilson and Goldsboro Experience. Rex-UNC Cardiovascular Symposium, Raleigh NC 2013
  29. Jobe, RL. TAVR: Where Are We Now, Where Are We Going? Presented at NC Chapter ACC Meeting. Asheville, NC. 2013
  30. Jobe, RL. TAVR: The Rex-UNC Experience. Grand Rounds, Department of Cardiothoracic Surgery, Chapel Hill, NC. 2013
  31. Jobe, RL. Advances and Treatments in Structural Heart Disease. Raleigh, NC 2013.

Research and Clinical Trials

  • PARAGON-B Trial, Hoffman-LaRoche: Lamifiban: IIB/IIIA in unstable angina/non-Q wave MI. 1999
  • AMISTAD-II Trial: adenosine as an adjunct to reperfusion therapy in acute anterolateral MI. 1999
  • ESPRIT: Randomized, double-blind placebo-controlled study to assess the efficacy and safety of the double-bolus integrilin dosing regimen in PCI with stent placement. 1999
  • AT-PAR: Randomized open label trial comparing outcomes in anti-platelet therapies for elective PCI/stenting. 1999
  • CREDO: Randomized, double-blind trial of Clopidogrel 300mg loading dose and 325 mg aspirin followed by Clopidogrel 75mg and aspirin daily compared with placebo loading followed by Clopidogrel 75mg and aspirin daily for the prevention of vascular events and all-cause mortality in patients undergoing PCI. 1999
  • BeStent 2: Non-randomized, prospective, consecutive- enrollment registry of patients with symptomatic ischemic heart disease due to stenotic lesions of the native coronary arteries that were amenable to PCI with stenting. 2000
  • EPHESUS: Randomized, double-blinded, placebo-controlled trial evaluating the safety and efficacy of eplerenone in patients with heart failure following acute myocardial infarction.
  • A to Z: Randomized, double-blinded trial to investigate the efficacy and tolerability of early treatment with simvastatin 40mg daily for 30 days, followed by simvastatin 80mg daily thereafter in tirofiban-treated acute coronary syndrome patients who have been randomized to receive enoxaparin or unfractionated heparin with aspirin. 2000
  • TRAP: Registry of the TRAP® Cardiovascular Filtration System (CFS) for use in patients with elevated enzymes/distal protection. 2000
  • REPLACE: Randomized, open-label study conducted in two parts evaluating angiomax in PCI to reduced clinical events. 2000
  • SYNERGY: Prospective, randomized, open-label study evaluating enoxaparin versus heparin in patients presenting with acute coronary syndrome. 2001
  • AIMI: Randomized study evaluating AngioJet thrombectomy followed by immediate PCI, versus immediate PCI only, in patients with AMI. 2001
  • TAXUS IV: Randomized, double blinded study comparing paclitaxel coated and bare metal Express stents. 2002
  • SYMBIOT: Randomized study to prevent distal embolization using a covered stent for de novo lesions in single and sequential svgs. 2002
  • VISIPAQUE/VALOR: Randomized, blinded study comparing Visipaque and Optiray in patients with chronic elevated creatinine (>1.5 females, >1.7 males). 2002
  • REPLACE 2: Randomized, double blinded study comparing bivalirudin alone to heparin + IIb/IIIa during PCI. 2002
  • SPIDER: Randomized study to prevent distal embolization using a basket downstream for de novo and restenotic lesions in single and sequential svgs. 2003
  • TAXUS V: Randomized, double blinded study comparing paclitaxel coated and bare metal Express stents. Complicated lesions, high risk patient population, and overlapping stents.
  • TIMI 32: Randomized, double blind, placebo controlled trial comparing to fVIIa/TF inhibitor, rNAPc2, plus enoxaparin compared to enoxaparin alone. Phase II study assessing dose range.
  • TIMI 30: Randomized, open label study comparing enoxaparin + eptifibitide, heparin + eptifibitide to bivalirudin alone. 2003
  • SYNTAX: Comparison of three vessel stenting to CABG for three vessel CAD. 2003
  • SPIRIT III: Randomized, blinded control trial of Everolimus coated stents to pacletaxel coated stents. 2003
  • SPIRIT IV: Randomized, blinded control trial of Everolimus coated stents to pacletaxel coated stents. 2004
  • COOL-RCN: Trial of intravascular cooling to prevent contrast nephropathy. 2006
  • COOL-AMI: Trial of intravascular cooling to reduce myocardial injury in AMI. 2006
  • TIMI 38: Randomized, double blinded study comparing prasugrel with clopidogrel in patients with ACS. 2006
  • ZOMAXX II: Randomized, blinded study evaluating the Zomaxx DES to the Taxus Express DES. 2006
  • CURRENT/OASIS: Randomized, double blinded study comparing a high loading dose of clopidogrel vs standard care in patients with UA or NSTEMI. 2006
  • PERSEUS: Randomized, blinded study comparing the Taxus Element DES to the Taxus Express DES. 2006
  • CEASE: Trial of new DUETT vascular closure device. 2007
  • ECLIPSE: Randomized study evaluating a femoral artery closure device. 2007
  • CHAMPION: Platform Randomized, double blinded study evaluating IV ticagrelor in ACS patients. 2007
  • CHAMPION CardioMeMs: Randomized, blinded study evaluating a wireless heart failure sensor in patients with Class III CHF. 2007
  • FREEDOM: Randomized study comparing CABG to PCI in diabetic patients with 3V disease. 2008
  • GRAVITAS: Randomized, double blinded study comparing 75mg clopidogrel to 150mg clopidogrel in patients deemed “non-responders” to clopidogrel, used with VerifyNow genetic assay test. 2008
  • CYPHER ELITE: Randomized, blinded study comparing the Cypher DES to the Cypher Elite DES. 2008
  • PLATINUM: Randomized, double blinded study comparing the Platinum Element DES to the Promus DES. 2009
  • HCRI DAPT: Randomized, double blinded study comparing 12 months dual anti-platelet therapy to 30 months dual anti-platelet therapy. 2010
  • TAXUS PMA: Randmized, double blinded study comparing 12 months of aspirin + prasugrel to 30 months aspirin + prasugrel in patients receiving a
  • TAXUS Liberte DES. 2010
  • GIFT Genotype information and functional testing study, a sub-study of GRAVITAS. 2010
  • SOLSTICE: Randomized, double blinded study evaluating losmapimod in NSTEMI patients. 2010
  • APPRAISE-2: Randomized, double blinded study evaluating a Factor X inhibitor in patients with recent ACS. 2010
  • AQUARIUS: Randomized, double blinded study evaluating the effects of aliskiren on coronary artery plaque regression. 2010
  • TAO Trial: Comparison of otamixaban Factor Xa inhibitor vs heparin and Integrilin in NSTEMI. 2012
  • EASY B2B: Heparin vs bivalrudin in Transradial PCI. 2012
  • Safe-PCI: Radial vs Femoral PCI in women. 2012
  • ION: Post-market ION stent registry. 2012
  • PEGASUS: Ticagrelor vs optimal medical care in post-MI patients. 2012
  • RIVER-PCI: Ranexa vs placebo in chronic angina with recent PCI and incomplete revascularization. 2012
  • EVOLVE II: Synergy DES with bioabsorbable polymer vs Element DES for CAD. 2013
  • ADVISE: Study comparing instantaneous flow reserve to fractional flow reserve in borderline and significant coronary lesions. 2013
  • ABSORB: Study of Bioabsorbable polymer coronary stent.2013
  • VEST: Study of Lifevest in post MI patients with reduced EF.2013


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